Guidelines used while developing the Internet Protocol stack, as conveyed by Dave Mills (a.k.a., Mr. NTP himself, creator of fuzzballs, original IP routers)
Would you trust your paycheck to the system?
Use unique timeouts such that even in combination they become signatures of where problems may exist. Use a different prime number for each to aid in discovering the combination of compounded timeouts.
The items above inspired at least one generation of his students; see Pezely's Posits.